Colling S B, Collinge J, Jefferys J G
Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College, London, UK.
Neurosci Lett. 1996 May 3;209(1):49-52. doi: 10.1016/0304-3940(96)12596-9.
The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that CA(2+)-activated K+ currents, in particular IAHP, are disrupted in PrP-null mice.
在缺乏朊病毒蛋白的小鼠（PrP基因敲除小鼠）中检测了海马CA1锥体细胞的内在特性。其静息电位、时间常数、中等后超极化（AHP）的幅度和动作电位发放适应性与对照组并无差异。PrP基因敲除组的不同之处在于其输入电阻较低，缺乏晚期AHP以及缺乏对蝎毒素敏感的总和AHP。我们认为，在PrP基因敲除小鼠中，Ca²⁺激活的K⁺电流，特别是IAHP，受到了破坏。
