Grimaldi G, McMahon-Pratt D
Departamento de Imunologia, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 1996 Jan-Feb;91(1):37-42. doi: 10.1590/s0074-02761996000100006.
Monoclonal antibodies specific for selected species complexes of Leishmania have been employed for the characterization of several representative strains of Leishmania isolated from different hosts and localities in the Americas. In the past 15 years, data have been accumulated concerning (i) the specificities of a number of these monoclonal antibodies and (ii) the antigenic variation (level of the expressed antigenic determinants) occurring among New World Leishmania species or strain variants as recognized by the monoclonal antibodies. This report is an attempt to summarize in brief the data accumulated to date on these points and to indicate the directions for future applications of these specific monoclonal antibodies for identification of leishmanial isolates.
针对利什曼原虫特定物种复合体的单克隆抗体已被用于鉴定从美洲不同宿主和地区分离出的几种代表性利什曼原虫菌株。在过去15年里，已经积累了有关以下两方面的数据：（i）许多此类单克隆抗体的特异性；（ii）新大陆利什曼原虫物种或菌株变体之间发生的抗原变异（表达的抗原决定簇水平），这些变异可被单克隆抗体识别。本报告旨在简要总结迄今在这些方面积累的数据，并指出这些特异性单克隆抗体在鉴定利什曼原虫分离株方面未来的应用方向。
