解析儿童抑郁行为中的遗传和非遗传变异。

Parsing the genetic and nongenetic variance in children's depressive behavior.

作者信息

Murray K T, Sines J O

机构信息

Department of Psychology, East University of Iowa, Iowa City 52242-1407, USA.

出版信息

J Affect Disord. 1996 Apr 26;38(1):23-34. doi: 10.1016/0165-0327(95)00089-5.

DOI:10.1016/0165-0327(95)00089-5

PMID:8735156

Abstract

Estimates of the genetic and environmental contributions to depressive behavior were derived using model-fitting analyses with data from a sample of 364 twin pairs, aged 4 to 12 years. Results suggested that genetic and nonshared environmental factors accounted for significant proportions of the variance in children's depressive symptomatology, but estimates differ for boys and girls. Further analyses indicated different genetic and environmental contributions for younger and older children. Analyses of a direct measure of shared and nonshared components of the environment identified specific aspects of children's environments which were associated with depressive behavior.

摘要

利用对364对年龄在4至12岁的双胞胎样本数据进行模型拟合分析，得出了遗传和环境因素对抑郁行为影响的估计值。结果表明，遗传因素和非共享环境因素在儿童抑郁症状的差异中占显著比例，但男孩和女孩的估计值有所不同。进一步分析表明，年龄较小和较大的儿童在遗传和环境因素的影响上存在差异。对环境中共享和非共享成分的直接测量分析确定了与抑郁行为相关的儿童环境的具体方面。