Kwan W H, Choi P H, Li C K, Shing M K, Chik K W, Yuen P, Chow L T
Department of Clinical Oncology, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Pediatr Hematol Oncol. 1996 May-Jun;13(3):277-85. doi: 10.3109/08880019609030828.
We describe two adolescent girls with alveolar rhabdomyosarcoma arising from extremities who developed bilateral breast metastasis in their clinical course. In both cases, there was widespread systemic disease at initial presentation. Although complete remission was achieved on the 25th week post-chemotherapy initiation, the first patient developed breast metastasis in addition to systemic recurrence on the 44th week and expired. For the second patient, breast metastasis was noted in addition to systemic disease at initial presentation. Aggressive chemotherapy with autologous transplant and radiotherapy were given in addition to bilateral subcutaneous total mastectomy. The patient remained in complete remission 3 months post-therapy. We postulate that adolescent females with alveolar rhabdomyosarcoma of the extremities have a high risk of developing breast metastasis in the pubertal period, and aggressive multidisciplinary treatment is indicated.
我们描述了两名患有四肢肺泡状横纹肌肉瘤的青春期女孩，她们在临床病程中出现了双侧乳腺转移。在这两个病例中，初诊时均已有广泛的全身疾病。尽管在开始化疗后的第25周实现了完全缓解，但第一名患者在第44周除全身复发外还出现了乳腺转移，并最终死亡。对于第二名患者，初诊时除全身疾病外还发现了乳腺转移。除双侧皮下全乳切除外，还进行了积极的化疗、自体移植和放疗。该患者在治疗后3个月仍处于完全缓解状态。我们推测，患有四肢肺泡状横纹肌肉瘤的青春期女性在青春期有发生乳腺转移的高风险，因此需要进行积极的多学科治疗。
