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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rieke F, Schwartz E A

Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637, USA.

J Physiol. 1996 May 15;493 ( Pt 1)(Pt 1):1-8. doi: 10.1113/jphysiol.1996.sp021360.

We have studied exocytosis and endocytosis in the synaptic terminal of salamander rods using a combination of Ca2+ imaging, capacitance measurement and the photolysis of Ca2+ buffers. 2. The average cytoplasmic Ca2+ concentration at the dark resting potential was 2-4 microM. 3. An average cytoplasmic Ca2+ concentration of 2-4 microM maintained a high rate of continuous exocytosis and endocytosis. 4. Changes in the rate of exocytosis were followed in less than 0.7 s by compensatory changes in the rate of endocytosis. 5. Vesicle cycling in the rod synapse is specialized for graded transmission and differs from that previously described for synapses that release synchronized bursts of transmitter.

我们结合钙离子成像、电容测量和钙离子缓冲剂光解技术，研究了蝾螈视杆细胞突触末端的胞吐作用和胞吞作用。2. 在暗静息电位下，细胞质中钙离子的平均浓度为2 - 4微摩尔。3. 2 - 4微摩尔的细胞质钙离子平均浓度维持着较高的连续胞吐和胞吞速率。4. 胞吐速率的变化在不到0.7秒内就会引起胞吞速率的补偿性变化。5. 视杆细胞突触中的囊泡循环专门用于分级传递，与之前描述的释放同步递质脉冲的突触不同。

Rieke F, Schwartz E A

Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637, USA.

J Physiol. 1996 May 15;493 ( Pt 1)(Pt 1):1-8. doi: 10.1113/jphysiol.1996.sp021360.

We have studied exocytosis and endocytosis in the synaptic terminal of salamander rods using a combination of Ca2+ imaging, capacitance measurement and the photolysis of Ca2+ buffers. 2. The average cytoplasmic Ca2+ concentration at the dark resting potential was 2-4 microM. 3. An average cytoplasmic Ca2+ concentration of 2-4 microM maintained a high rate of continuous exocytosis and endocytosis. 4. Changes in the rate of exocytosis were followed in less than 0.7 s by compensatory changes in the rate of endocytosis. 5. Vesicle cycling in the rod synapse is specialized for graded transmission and differs from that previously described for synapses that release synchronized bursts of transmitter.

我们结合钙离子成像、电容测量和钙离子缓冲剂光解技术，研究了蝾螈视杆细胞突触末端的胞吐作用和胞吞作用。2. 在暗静息电位下，细胞质中钙离子的平均浓度为2 - 4微摩尔。3. 2 - 4微摩尔的细胞质钙离子平均浓度维持着较高的连续胞吐和胞吞速率。4. 胞吐速率的变化在不到0.7秒内就会引起胞吞速率的补偿性变化。5. 视杆细胞突触中的囊泡循环专门用于分级传递，与之前描述的释放同步递质脉冲的突触不同。