Colacurci N, Fortunato N, De Franciscis P, Fratta M, Cioffi M, Zarcone R, Cardone A
2nd Department of Gynecology and Obstetrics, School of Medicine, Second University of Naples, Italy.
Eur J Obstet Gynecol Reprod Biol. 1996 May;66(1):41-3. doi: 10.1016/0301-2115(95)02372-0.
To evaluate the clinical utility of CA-125 in the diagnosis of endometriosis and to compare the sensitivity of the serum and the peritoneal test as indicator of disease.
Peritoneal fluid was obtained at laparoscopy. The quantitative determination of CA-125 in serum and in peritoneal fluid was performed by IRMA-mat CA-125 'two-step method', a two-site immunoradiometric assay, using 35 and 60 U/ml as cutoff.
Second Department of Gynecology and Obstetrics, Second University of Naples, Italy.
A total of 26 women infertile undergoing diagnostic laparoscopy that exhibited endometriosis in 14 patients, normal pelvis in 12 patients (control group).
None.
CA-125 levels in peritoneal fluid were higher than those found in serum and were significantly elevated (P < 0.05), when compared with the control group, both in women with endometriosis stage I-II and stage III-IV. In serum, CA-125 levels increased only in advanced stage of endometriosis.
Levels of CA-125 in peritoneal fluid seem to be a more sensitive indicator of disease than serum levels (0.86 vs. 0.36), especially in early stage endometriosis (0.80 vs. 0.20) which tends to be overlooked by the CA-125 serum test.
评估CA - 125在子宫内膜异位症诊断中的临床应用价值，并比较血清和腹腔液检测作为疾病指标的敏感性。
在腹腔镜检查时获取腹腔液。采用IRMA - mat CA - 125“两步法”（一种双位点免疫放射分析方法）对血清和腹腔液中的CA - 125进行定量测定，以35和60 U/ml作为临界值。
意大利那不勒斯第二大学妇产科第二科室。
共有26例不孕女性接受诊断性腹腔镜检查，其中14例患有子宫内膜异位症，12例盆腔正常（对照组）。
无。
腹腔液中CA - 125水平高于血清中的水平，且与对照组相比，I - II期和III - IV期子宫内膜异位症女性的腹腔液CA - 125水平均显著升高（P < 0.05）。在血清中，CA - 125水平仅在子宫内膜异位症晚期升高。
腹腔液中CA - 125水平似乎比血清水平更能敏感地反映疾病（0.86对0.36），尤其是在早期子宫内膜异位症中（0.80对0.20），而血清CA - 125检测往往会忽略早期病例。
