Kraus S J, Jacobs N F, Chandler F W, Arum E S
Infect Immun. 1977 Apr;16(1):302-9. doi: 10.1128/iai.16.1.302-309.1977.
Subcutaneous tissue cavities in mice and guinea pigs were infected with human isolates of Ureaplasma urealyticum and Mycoplasma hominis. The minimal infective dose for M. hominis was as low as less than 10 color-changing units (CCU) for mice and 10(2) CCU for guinea pigs. The minimal infective dose for U. urealyticum was as low as less than 10 CCU for mice and 10(4) CCU for guinea pigs. Mouse infections with either U. urealyticum or M. hominis persisted for 1 day to greater than 4 months. Guinea pigs remained infected for up to 4 weeks. Two M. hominis isolates were similar in their ability to infect subcutaneous tissue cavities but two U. urealyticum isolates varied in their ability to infect the cavities. The histopathology of the M. hominis and U. urealyticum infections was similar: an initial intense polymorphonuclear response with giant cells, followed in 4 weeks by histiocytes and giant cells with some plasma cells and lymphocytes.
将解脲脲原体和人型支原体的人类分离株感染小鼠和豚鼠的皮下组织腔。人型支原体对小鼠的最小感染剂量低至小于10个颜色变化单位（CCU），对豚鼠为10² CCU。解脲脲原体对小鼠的最小感染剂量低至小于10 CCU，对豚鼠为10⁴ CCU。用解脲脲原体或人型支原体感染小鼠可持续1天至超过4个月。豚鼠的感染可持续长达4周。两株人型支原体分离株感染皮下组织腔的能力相似，但两株解脲脲原体分离株感染这些腔的能力有所不同。人型支原体和解脲脲原体感染的组织病理学相似：最初是强烈的多形核细胞反应并伴有巨细胞，4周后出现组织细胞和巨细胞，并伴有一些浆细胞和淋巴细胞。
