Martins C, Fonseca I, Roque L, Pinto A E, Soares J
Departamento de Patologia Morfológica, Instituto Português de Oncologia de Francisco Gentil, Lisboa, Portugal.
Eur J Cancer B Oral Oncol. 1996 Mar;32B(2):128-32. doi: 10.1016/0964-1955(95)00078-x.
A group of 19 malignant salivary gland neoplasms of various histological types (mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, myoepithelial carcinoma, basal cell adenocarcinoma, carcinoma ex-pleomorphic adenoma, ductal carcinoma, adenocarcinoma not otherwise specified and undifferentiated carcinoma) were cytogenetically investigated. Previous karyotypic information revealed deletion of the long arm of chromosome 6, loss of chromosome Y and the gain of chromosome 8 as the most recurrent deviations found in these neoplasms. Clonal chromosome aberrations were detected in 11 cases of this series. In 7 of them there were only numerical deviations (gain of chromosomes 2, 7, 8, 10 and X and loss of chromosomes 18, 21 and Y) without concomitant structural anomalies. Structural rearrangements such as t(2;7), t(6;16), t(6;9) and t(1;1) translocations were found in two mucoepidermoid carcinomas, one adenoid cystic carcinoma and one ductal carcinoma, respectively. The wide spectrum of changes found in this group of neoplasms may reflect the diversity in their histogenesis and differentiation phenotypes.
对一组19例不同组织学类型的恶性涎腺肿瘤（黏液表皮样癌、腺泡细胞癌、腺样囊性癌、上皮-肌上皮癌、肌上皮癌、基底细胞腺癌、多形性腺瘤癌变、导管癌、未另行规定的腺癌和未分化癌）进行了细胞遗传学研究。先前的核型信息显示，6号染色体长臂缺失、Y染色体丢失和8号染色体增加是这些肿瘤中最常见的异常情况。在该系列的11例病例中检测到克隆性染色体畸变。其中7例仅有数目异常（2号、7号、8号、10号和X染色体增加，18号、21号和Y染色体丢失），无伴随的结构异常。在2例黏液表皮样癌、1例腺样囊性癌和1例导管癌中分别发现了t(2;7)、t(6;16)、t(6;9)和t(1;1)易位等结构重排。在这组肿瘤中发现的广泛变化可能反映了它们在组织发生和分化表型上的多样性。
