Targowski S P, Abeyounis C J, Milgrom F
Int Arch Allergy Appl Immunol. 1977;54(3):262-8. doi: 10.1159/000231835.
Cryostat sections of methylcholanthrene-induced murine tumors were previously shown to adsorb erythocytes sensitized by subagglutinating concentrations of antierythocyte antibodies. This type of hemadsorption was seen also with sections of normal murine spleen. It was shown in the present study that immune complexes composed of bovine serum albumin (BSA) and rabbit anti-BSA serum, or human IgG and mouse anti-human IgG serum inhibit adsorption of sensitized erythocytes by tumor and spleen sections. Maximum inhibition was produced by complexes formed at excess of antigen. In contrast inhibition was not seen with complexes formed at equivalence. In addition, heat-aggregated human IgG, but not monomeric human IgG, inhibited hemadsorption by tumor tissue. Anti-BSA, antihuman IgG, BSA or human IgG alone did not produce significant inhibition. These results support the contention that murine tumor cell and lymphocytes have similar Fc receptors on their surface. The implication that the nonspecific attachment of immune complexes to the tumor cells and lymphocytes may alter the immunological response of the host to the tumor is discussed.
先前已表明，甲基胆蒽诱导的小鼠肿瘤的低温切片能吸附由亚凝集浓度的抗红细胞抗体致敏的红细胞。正常小鼠脾脏切片也可见这种类型的血细胞吸附现象。本研究表明，由牛血清白蛋白（BSA）和兔抗BSA血清或人IgG和小鼠抗人IgG血清组成的免疫复合物可抑制肿瘤和脾脏切片对致敏红细胞的吸附。抗原过量形成的复合物产生最大抑制作用。相比之下，等价形成的复合物未见抑制作用。此外，热聚集的人IgG而非单体人IgG可抑制肿瘤组织的血细胞吸附。单独的抗BSA、抗人IgG、BSA或人IgG未产生显著抑制作用。这些结果支持了小鼠肿瘤细胞和淋巴细胞表面具有相似Fc受体的观点。讨论了免疫复合物与肿瘤细胞和淋巴细胞的非特异性结合可能改变宿主对肿瘤的免疫反应这一观点。
