Henriksen T O, Law L W
Int J Cancer. 1977 Jun 15;19(6):866-9. doi: 10.1002/ijc.2910190619.
Tumour-growth-promoting activity has been observed in ascitic fluids of mice with progressively growing SV40- and chemically induced tumours. Administration of ascitic fluid to animals together with a normally non-tumorigenic dose of SV40- transformed tissue culture cells (TU-5) will cause these cells to grow progressively and eventually kill the animals. Also, the mKSA-specfic, immunologically non-responsive state (the eclipse phase) of mice bearing large mKSA tumours can be maintained by administration of ascitic fluid or serum from tumour-bearing animals after the tumours have been surgically removed. Normally, complete immunity to a secondary tumour cell challenge is re-established approximately 10 days after removal of the primary tumour, but daily injections of ascitic fluid or serum will maintain sclipse so that a secondary challenge of tumour cells will grow progressively. The active component apparently acts non-specifically, since ascitic fluid from an unrelated tumour also is able to maintain the mKSA-specific eclipse phase. Thascitic fluid has no apparent immunosuppressive activity in vivo.
在患有逐渐生长的SV40诱导肿瘤和化学诱导肿瘤的小鼠腹水中，已观察到肿瘤生长促进活性。将腹水与通常非致瘤剂量的SV40转化组织培养细胞（TU-5）一起给予动物，会导致这些细胞逐渐生长并最终杀死动物。此外，在大mKSA肿瘤的小鼠被手术切除肿瘤后，通过给予来自荷瘤动物的腹水或血清，可以维持其mKSA特异性免疫无反应状态（隐匿期）。正常情况下，在切除原发肿瘤后约10天会重新建立对二次肿瘤细胞攻击的完全免疫，但每天注射腹水或血清会维持隐匿期，从而使肿瘤细胞的二次攻击能够逐渐生长。活性成分显然是非特异性起作用的，因为来自无关肿瘤的腹水也能够维持mKSA特异性隐匿期。腹水在体内没有明显的免疫抑制活性。
