Yoshioka M, Matsumoto M, Togashi H, Saito H
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
Neurosci Lett. 1996 May 17;209(3):201-3. doi: 10.1016/0304-3940(96)12631-8.
The effects of conditioned fear stress (CFS) on dopamine release in the medial prefrontal cortex were studied by in vivo microdialysis in the rat. CFS (exposure to an environment in which foot-shock had been delivered previously) induced a marked suppression of motility, i.e., freezing behavior. Extracellular concentrations of dopamine in the medial prefrontal cortex were increased by CFS. The increase of dopamine returned to the pretreatment levels when rats were returned to the home cages. Diazepam (0.5 mg/kg, i.p.) suppressed both the CFS-induced freezing behavior and extracellular dopamine levels in the medial prefrontal cortex. These findings suggest that anxiety and dopamine release in the prefrontal cortex might be related.
通过对大鼠进行体内微透析，研究了条件性恐惧应激（CFS）对内侧前额叶皮质中多巴胺释放的影响。CFS（暴露于先前曾施加过足部电击的环境）诱导了运动能力的显著抑制，即僵住行为。内侧前额叶皮质中多巴胺的细胞外浓度因CFS而升高。当大鼠回到饲养笼时，多巴胺的升高恢复到预处理水平。地西泮（0.5毫克/千克，腹腔注射）抑制了CFS诱导的僵住行为以及内侧前额叶皮质中的细胞外多巴胺水平。这些发现表明，焦虑与前额叶皮质中的多巴胺释放可能有关。
