Hara A, Uemura K, Taketomi T
Research Center on Aging and Adaptation Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Glycoconj J. 1996 Apr;13(2):187-94. doi: 10.1007/BF00731493.
Sulfatides (galactosylceramide I3-sulfate), which are found in serum lipoproteins of various mammals, effectively increased prothrombin time (anticoagulant effect) and also effectively prolonged bleeding time (anti-platelet effect). When equal volumes of a homogeneous micellar solution of sulfatide and fibrinogen in phosphate-buffered saline were mixed, an insoluble complex precipitated. Analysis of the precipitated complex showed that the molar ratio of sulfatide to fibrinogen was about 400:1. These results indicate that the sulfatide micelle binds tightly to fibrinogen and thereby interferes with both fibrin gel formation (anticoagulant activity) and platelet function.
硫苷脂（半乳糖神经酰胺硫酸酯）存在于各种哺乳动物的血清脂蛋白中，它能有效延长凝血酶原时间（抗凝作用），也能有效延长出血时间（抗血小板作用）。当将等体积的硫苷脂和纤维蛋白原在磷酸盐缓冲盐水中的均匀胶束溶液混合时，会沉淀出一种不溶性复合物。对沉淀复合物的分析表明，硫苷脂与纤维蛋白原的摩尔比约为400:1。这些结果表明，硫苷脂胶束与纤维蛋白原紧密结合，从而干扰纤维蛋白凝胶的形成（抗凝活性）和血小板功能。
