Murphy B, Sayegh M H
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Curr Opin Nephrol Hypertens. 1996 May;5(3):262-8. doi: 10.1097/00041552-199605000-00012.
Recent advances with regard to the structure and function of the major histocompatibility molecules have given rise to a better understanding of T cell receptor interaction with the major histocompatibility complex plus peptide complex on the surface of antigen-presenting cells, and have highlighted the pivotal role of the peptide in determining the subsequent T cell response. There has therefore been increased interest in the use of synthetic peptides to alter T cell responses to foreign antigens. The purpose of this review is to highlight the recent studies which demonstrate the potential immunomodulatory functions of peptides derived from major histocompatibility complex molecules.
