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Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways.主要组织相容性复合体II类分子对内部合成抗原的递呈表现出细胞类型变异性，并与外源性II类分子和内源性I类分子递呈途径相分离。
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Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses.母鸡溶菌酶的构象稳定性对2型辅助性T细胞免疫反应诱导的贡献。
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Repression of major histocompatibility complex IA expression by glucocorticoids: the glucocorticoid receptor inhibits the DNA binding of the X box DNA binding protein.糖皮质激素对主要组织相容性复合体IA表达的抑制作用：糖皮质激素受体抑制X盒DNA结合蛋白的DNA结合。
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Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.乙型肝炎病毒末端蛋白区域的表达抑制细胞对α干扰素、γ干扰素和双链RNA的反应。
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2888-92. doi: 10.1073/pnas.88.7.2888.
9
Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.II类主要组织相容性复合体分子存在于巨噬细胞的溶酶体和吞噬溶酶体中，这些细胞器在单核细胞增生李斯特菌的吞噬处理过程中发挥作用，以便将其呈递给T细胞。
J Cell Biol. 1992 Nov;119(3):531-42. doi: 10.1083/jcb.119.3.531.

本文引用的文献

1
Determinant selection is a macrophage dependent immune response gene function.决定簇选择是一种巨噬细胞依赖性免疫反应基因功能。
Nature. 1977 May 12;267(5607):156-8. doi: 10.1038/267156a0.
2
Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.氨和氯喹引起的巨噬细胞抗原分解代谢减少与抗原呈递给T细胞的抑制相关。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):175-8. doi: 10.1073/pnas.79.1.175.
3
Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.H-2 限制性 T 细胞的抗原识别。II. 一种替代加工抗原的胰蛋白酶消化卵清蛋白肽。
J Immunol. 1984 Oct;133(4):2067-74.
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Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.半抗原特异性B淋巴细胞的抗原呈递。I. 表面免疫球蛋白受体的作用。
J Exp Med. 1984 Oct 1;160(4):1102-13. doi: 10.1084/jem.160.4.1102.
5
Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas.巨噬细胞对溶菌酶的加工处理：两种T细胞杂交瘤识别的决定簇的鉴定。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2489-93. doi: 10.1073/pnas.81.8.2489.
6
Inhibition of antigen-specific T lymphocyte activation by structurally related Ir gene-controlled polymers. Evidence of specific competition for accessory cell antigen presentation.结构相关的Ir基因控制的聚合物对抗原特异性T淋巴细胞激活的抑制作用。辅助细胞抗原呈递特异性竞争的证据。
J Exp Med. 1983 May 1;157(5):1618-34. doi: 10.1084/jem.157.5.1618.
7
Chemically related antigens compete for presentation by accessory cells to T cells.化学相关抗原竞争由辅助细胞呈递给T细胞。
J Immunol. 1982 Nov;129(5):1883-91.
8
Macrophage endosomes contain proteases which degrade endocytosed protein ligands.巨噬细胞内体含有可降解内吞蛋白配体的蛋白酶。
J Biol Chem. 1985 Dec 5;260(28):15311-7.
9
Binding of immunogenic peptides to Ia histocompatibility molecules.免疫原性肽与Ia组织相容性分子的结合。
Nature. 1985;317(6035):359-61. doi: 10.1038/317359a0.
10
Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells.抗原与Ia相互作用及被T细胞识别所需的结构特征。
Nature. 1987;328(6129):395-9. doi: 10.1038/328395a0.

Cellular mechanisms of antigen processing and the function of class I and II major histocompatibility complex molecules.

作者信息

Harding C V, Unanue E R

机构信息

Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

Cell Regul. 1990 Jun;1(7):499-509. doi: 10.1091/mbc.1.7.499.

DOI:10.1091/mbc.1.7.499
PMID:2098113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361562/
Abstract
摘要