Bardgett M E, Newcomer J W, Taylor G T
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
Physiol Behav. 1996 Jun;59(6):1111-5. doi: 10.1016/0031-9384(95)02172-8.
Acquisition and reversal of a memory task dependent on hippocampal integrity were assessed in rats following chronic corticosterone treatment. Young adult male rats were injected daily with corticosterone (10 mg/kg, SC) for 8 weeks. Memory was assessed during the last week of treatment with an elevated platform maze. During acquisition trials, corticosterone-treated rats did not differ from vehicle-treated controls in either the location of first hole chosen nor in the latency to locate the escape hole. In the reversal trials, when the position of the escape hole was rotated 135 degrees, both groups successfully reversed their responses without persevering towards the previously rewarded escape hole location. These findings suggest that, despite the probability of corticosterone-induced changes in hippocampal physiology, chronic corticosterone treatment does not adversely affect performance in a memory task dependent on hippocampal integrity.
在慢性皮质酮处理后的大鼠中，评估了依赖海马完整性的记忆任务的获得和逆转情况。成年雄性幼鼠每天皮下注射皮质酮（10mg/kg），持续8周。在治疗的最后一周，用高架平台迷宫评估记忆。在获得试验期间，皮质酮处理的大鼠在选择的第一个洞的位置或找到逃生洞的潜伏期方面与溶剂处理的对照组没有差异。在逆转试验中，当逃生洞的位置旋转135度时，两组都成功地逆转了它们的反应，没有执着于先前奖励的逃生洞位置。这些发现表明，尽管皮质酮可能会引起海马生理变化，但慢性皮质酮处理不会对依赖海马完整性的记忆任务的表现产生不利影响。
