Jin R, Kurashige S
Department of Medical Technology, College of Medical Care and Technology, Gunma University, Japan.
Am J Chin Med. 1996;24(1):37-44. doi: 10.1142/S0192415X96000062.
The effect of Shi-ka-ron (CX) on cytokine production of lymphocytes in mice treated with cyclophosphamide was investigated. Shi-ka-ron, a traditional Chinese prescription, consists of 8 crude Chinese herbal extracts. Its main efficacy is to strengthen the body resistance. We observed that each CX component stimulated interleukine-2 and interferon-gamma production of murine splenic lymphocytes both in vitro and in vivo. IL-2 and IFN-gamma production of splenic lymphocytes were also examined in mice treated with CX combined with cyclophosphamide (CY) in vivo. We found that CX not only could increase IL-2 and IFN-gamma production in vitro, but also in vivo at suboptimal concentration.
研究了十加仑（CX）对环磷酰胺处理的小鼠淋巴细胞细胞因子产生的影响。十加仑是一种中药方剂，由8种中药粗提物组成。其主要功效是增强机体抵抗力。我们观察到，CX的每个成分在体外和体内均能刺激小鼠脾淋巴细胞产生白细胞介素-2和γ-干扰素。还在体内用CX联合环磷酰胺（CY）处理的小鼠中检测了脾淋巴细胞的IL-2和IFN-γ产生。我们发现，CX不仅能在体外增加IL-2和IFN-γ的产生，而且在次优浓度下在体内也能增加。
