Jin R, Wan L L, Mitsuishi T, Sato S, Akuzawa Y, Kodama K, Kurashige S
Department of Internal Medicine, Zhejiang College of Traditional Chinese Medicine Hospital, Hougzhou.
Am J Chin Med. 1994;22(3-4):255-66. doi: 10.1142/S0192415X94000310.
Shi-Ka-Ron is a prescription composed of 8 crude extracts of Chinese herbs. It reduces suppression of cytokine production by peritoneal macrophages in mice Immunocompromised by the anti-tumor agent, cyclophosphamide (CY), in vivo. Although it dose not increase IL-1 production in vitro, it enhances TNF production. We found that Ginseng radix, Lithospermi radix, Astragli radix and Glycyrrhizae radix somewhat reduced suppression of cytokine production in CY treated macrophages. Especially, Glycyrrhizae radix shows an active immune response both in vivo and in vitro. Our results suggested that the mechanism underlying immunomodulation of Shi-Ka-Ron is closely related to cytokine production: each herb stimulating macrophages.
十加龙是一种由8种中药粗提取物组成的方剂。它可减轻体内因抗肿瘤药物环磷酰胺（CY）导致免疫受损的小鼠腹腔巨噬细胞对细胞因子产生的抑制作用。虽然它在体外不会增加白细胞介素-1的产生，但会增强肿瘤坏死因子的产生。我们发现人参、紫草、黄芪和甘草在一定程度上减轻了CY处理的巨噬细胞对细胞因子产生的抑制作用。特别是，甘草在体内和体外均表现出活跃的免疫反应。我们的结果表明，十加龙免疫调节的机制与细胞因子的产生密切相关：每种草药都能刺激巨噬细胞。
