Spengler D M, Baylink D J, Rosenquist J B
J Bone Joint Surg Am. 1977 Jul;59(5):670-2.
In vivo beta-aminopropionitrile treatment caused significant changes in the mechanical properties of rat femora. In femora treated with beta-aminopropinitrile as compared with controls, there was a 44 per cent decrease in bone stiffness and a 47 per cent increase in bone deformation to failure. Bone ash was decreased 5 per cent in the treated group. It is likely that the decrease in bone ash was secondary to impaired intermolecular bone-collagen cross-linking, which is a well established consequence of treatment with beta-aminopropionitrile. Thus, beta-aminopropionitrile influences bone mechanical properties directly by impairing collagen cross-linking and indirectly by altering bone-matrix mineralization.
体内β-氨基丙腈处理导致大鼠股骨力学性能发生显著变化。与对照组相比，用β-氨基丙腈处理的股骨骨硬度降低了44%，骨折时的骨变形增加了47%。处理组的骨灰减少了5%。骨灰减少可能是分子间骨胶原交联受损的继发结果，这是β-氨基丙腈处理的一个公认后果。因此，β-氨基丙腈通过损害胶原交联直接影响骨力学性能，并通过改变骨基质矿化间接影响骨力学性能。
