Ogoshi K, Moriyama T, Nanzai Y
Dept of Public Health, Nara Medical University, Japan.
Arch Toxicol. 1989;63(4):320-4. doi: 10.1007/BF00278646.
The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. The adult rats were subdivided into six groups, administered 0, 10, 20, 40, 80 and 160 ppm cadmium, respectively. The old rats were divided into three subgroups, which were administered 0, 80, and 160 ppm cadmium, respectively. The length of the administration was 4 weeks in every group. The decrease in the mechanical strengths of bones of young rats administered with cadmium was observed. On the other hand, no change in mechanical strength of bones was observed in the case of adult and old rats, administered up to 160 ppm cadmium. The correlation between the cadmium in bones and the decrease in the strength of the bone shows that cadmium directly affects the mechanical properties of bones of young rats.
为了证明镉对幼鼠骨骼的直接影响，对给予不同浓度镉的幼龄、成年和老龄大鼠的骨骼力学性能进行了测量。幼鼠被分为三个亚组，分别给予0（对照）、5和10 ppm的镉。成年大鼠被细分为六组，分别给予0、10、20、40、80和160 ppm的镉。老龄大鼠被分为三个亚组，分别给予0、80和160 ppm的镉。每组的给药时长均为4周。观察到给予镉的幼鼠骨骼力学强度下降。另一方面，给予高达160 ppm镉的成年和老龄大鼠，其骨骼力学强度未观察到变化。骨骼中的镉与骨骼强度下降之间的相关性表明，镉直接影响幼鼠骨骼的力学性能。
