Niwano Y, Koga H, Sakai A, Kanai K, Hamaguchi H, Uchida M, Tachikawa T
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd., Osaka, Japan.
Arzneimittelforschung. 1996 Apr;46(4):450-5.
The wound healing effect of malotilate (CAS 59937-28-9, NKK-105) was investigated by using an excisional skin-wound model produced on the back of normal and healing-impaired (induced by prednisolone pretreatment) rats. The rapid decrease in the square measure of wound areas and the improvement in the histological evaluation clarified that 0.3% and 1% cream preparations of malotilate were obviously effective in accelerating spontaneous healing in the normal rats. The accelerative effect of malotilate cream preparations was likely superior to that of an ointment containing 5% deproteinized calf blood extract used as a reference agent. The same effect was also observed in the healing-impaired rats. The histological findings revealed that a thicker and more cellular granulation tissue, which in turn created an adequate bed for rapid re-epithelization, was formed in the malotilate-treated animals. Acceleration of granulation tissue formation by malotilate was also supported by the cotton pellet implantation method. It is concluded from these results that malotilate seems to be a promising agent for topical wound therapy.
通过在正常大鼠和愈合受损（由泼尼松龙预处理诱导）大鼠背部制作切除性皮肤伤口模型，研究了马洛替酯（CAS 59937-28-9，NKK-105）的伤口愈合效果。伤口面积平方测量值的迅速减小以及组织学评估的改善表明，0.3%和1%的马洛替酯乳膏制剂在加速正常大鼠的自发愈合方面具有明显效果。马洛替酯乳膏制剂的加速效果可能优于用作参考剂的含5%脱蛋白小牛血提取物的软膏。在愈合受损的大鼠中也观察到了相同的效果。组织学结果显示，在接受马洛替酯治疗的动物中形成了更厚且细胞更多的肉芽组织，这反过来又为快速重新上皮化创造了合适的基础。棉球植入法也支持马洛替酯对肉芽组织形成的加速作用。从这些结果得出结论，马洛替酯似乎是一种有前景的局部伤口治疗药物。
