Massari M, Salvarani C, Portioli I, Ramazzotti E, Gabbi E, Bonazzi L
Division of Infectious Disease, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Infection. 1996 Mar-Apr;24(2):159-61. doi: 10.1007/BF01713327.
A case of polyarteritis nodosa identified by the American College of Rheumatology (ACR) 1990 criteria in a 44-year-old HIV-infected man is described. The search for cytomegalovirus, HBV and B19 parvovirus infections was negative. In situ hybridization did not reveal proviral HIV-1 DNA in a skin sample. A zidovudine-associated vasculitis was excluded. Corticosteroid therapy resolved vasculitis manifestations and was well tolerated without opportunistic infections during the 10-month follow-up period. An indirect pathogenetic role of HIV as a possible cause of vascular damage cannot be excluded in our patient.
本文描述了一例44岁的HIV感染男性患者，根据美国风湿病学会（ACR）1990年标准确诊为结节性多动脉炎。对巨细胞病毒、HBV和B19细小病毒感染的检查均为阴性。原位杂交未在皮肤样本中检测到HIV-1前病毒DNA。排除了齐多夫定相关血管炎。在10个月的随访期内，皮质类固醇治疗使血管炎表现得到缓解，且耐受性良好，未发生机会性感染。在我们的患者中，不能排除HIV作为血管损伤可能原因的间接致病作用。
