Korshunov V A, Wiener S I, Korshunova T A, Berthoz A
CNRS-Collège de France Laboratoire de Physiologie de la Perception de l'Action UMR-C 9950, Paris, France.
Exp Brain Res. 1996 Apr;109(1):169-73. doi: 10.1007/BF00228640.
To test for access of spatial cues to the hippocampus of unrestrained animals, single unit recordings of CA1 complex spike cells were made in thirsty rats as they made alternating visits between the center and corners of an enclosed 60 x 60 cm square arena. At intervals, all lights were turned off in the arena and it was rotated. Although no neuronal discharge activity was found that encoded the rotation angle, 11 of 97 neurons were selectively activated after lights were turned off or on. This activity began at delays of up to several seconds and persisted for tens of seconds. These discharges had no location selectivity or behavioral correlates and continued even as the rat performed several behaviors in different parts of the arena. This confirms similar results in restrained rabbits while showing for the first time that this neuronal activity can be independent of place and behavior. In addition this shows that sensory stimuli can trigger hippocampal discharges even when the rat is not required to make any behavioral responses to them.
为了测试空间线索对不受约束动物海马体的影响，在口渴的大鼠交替进出一个60×60平方厘米封闭方形场地的中心和角落时，对其CA1复合棘波细胞进行单单元记录。每隔一段时间，场地内所有灯光关闭并旋转场地。尽管未发现编码旋转角度的神经元放电活动，但97个神经元中有11个在灯光关闭或打开后被选择性激活。这种活动在长达数秒的延迟后开始，并持续数十秒。这些放电没有位置选择性或行为相关性，即使大鼠在场地的不同部位进行多种行为时仍会持续。这证实了在约束状态下兔子的类似结果，同时首次表明这种神经元活动可以独立于位置和行为。此外，这表明即使大鼠不需要对感觉刺激做出任何行为反应，感觉刺激也能触发海马体放电。
