Blennow M, Rosengren L, Jonsson S, Forssberg H, Katz-Salamon M, Hagberg H, Hesser U, Lagercrantz H
Department of Woman and Child Health, Karolinska Institute Stockholm, Sweden.
Acta Paediatr. 1996 Apr;85(4):485-9. doi: 10.1111/j.1651-2227.1996.tb14068.x.
Glial fibrillary acidic protein (GFAP) is the structural protein of the intermediate filament of astroglia. The aims of the present study were to examine GFAP in the cerebrospinal fluid (CSF) of preterm infants at different postmenstrual ages and to evaluate the potential of GFAP to predict abnormal neurodevelopmental outcome. GFAP increased in correlation with postmenstrual age in preterm infants (n = 17) and full-term infants (n = 9). The levels were five times higher in preterm infants (n = 10) with an abnormal neonatal course and/or an abnormal neurological outcome than in healthy preterm infants. The positive predictive value of a GFAP higher than the 98th percentile of normal infants was 69%, while a GFAP level below this limit invariable predicted a good outcome. Simultaneously analysed noradrenaline, hypoxanthine and glutamate did not differ between the groups. We conclude that CSF GFAP increases with maturity and that CSF GFAP appears to be a promising marker for perinatal brain damage.
胶质纤维酸性蛋白（GFAP）是星形胶质细胞中间丝的结构蛋白。本研究的目的是检测不同月经龄早产儿脑脊液（CSF）中的GFAP，并评估GFAP预测异常神经发育结局的潜力。GFAP在早产儿（n = 17）和足月儿（n = 9）中与月经龄呈正相关。有异常新生儿病程和/或异常神经学结局的早产儿（n = 10）的GFAP水平比健康早产儿高五倍。GFAP高于正常婴儿第98百分位数的阳性预测值为69%，而低于此限值的GFAP水平始终预测结局良好。同时分析的去甲肾上腺素、次黄嘌呤和谷氨酸在各组之间无差异。我们得出结论，脑脊液GFAP随成熟度增加，脑脊液GFAP似乎是围产期脑损伤的一个有前景的标志物。
