Okita R T, Okita J R
Department of Pharmaceutical Sciences, Washington State University, Pullman 99164-6510, USA.
Crit Rev Biochem Mol Biol. 1996 Apr;31(2):101-26. doi: 10.3109/10409239609106581.
Prostaglandins E2 and F2 alpha regulate a number of physiological functions in reproductive tissues, and concentrations of these bioactive modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing enzymes induced during pregnancy are NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450-dependent prostaglandin omega- or 20-hydroxylase. This review discusses the biochemical properties, regulation, and possible functions of these three enzymes.
前列腺素E2和F2α调节生殖组织中的多种生理功能，且这些生物活性调节剂的浓度在孕期会升高。与孕期循环中前列腺素水平升高相对应的是代谢这些物质的酶的增加。孕期诱导产生的三种前列腺素代谢酶分别是NAD(+)依赖性15-羟基前列腺素脱氢酶（PGDH）、NADPH依赖性羰基还原酶和细胞色素P450依赖性前列腺素ω-或20-羟化酶。本文综述了这三种酶的生化特性、调节机制及可能的功能。
