Zamberlan N, Radetti G, Paganini C, Gatti D, Rossini M, Braga V, Adami S
Cattedra di Reumatologia, Ospedale di Valeggio, Verona, Italy.
Eur J Pediatr. 1996 May;155(5):377-82. doi: 10.1007/BF01955265.
The bone mineral content (BMC) and the cortical thickness at the distal radius and at the II metacarpal were assessed in growing individuals (167 females and 158 males) by radiometric and quantitative roentgen microdensitometric methods. BMC adjusted for age and pubertal status was significantly higher in males than in females. However, the BMC corrected for bone volume (volumetric bone density, g/cm3) and the metacarpal cortical index (cortical area/total area) were identical in males and females. BMC rose progressively with age, approaching a plateau by the end of puberty. Lower but still significant increases with age were also observed for volumetric bone density of the metacarpus and the metacarpal index. These increases were also most marked by the end of pubertal maturation and might be related to diminution of bone turnover.
This study provides the normative data of bone mass in growing individuals by making use of a reasonably accurate and easily available technique. The results obtained indicate that most of the differences between males and females and the changes with age are related to changes in skeletal dimension rather than density.
采用放射测量法和定量X线显微密度测定法，对生长发育期个体（167名女性和158名男性）的桡骨远端和第二掌骨的骨矿物质含量（BMC）及皮质厚度进行了评估。校正年龄和青春期状态后的BMC，男性显著高于女性。然而，校正骨体积后的BMC（体积骨密度，g/cm³）及掌骨皮质指数（皮质面积/总面积）在男性和女性中相同。BMC随年龄逐渐上升，青春期结束时接近平台期。掌骨的体积骨密度和掌骨指数随年龄也有较低但仍显著的增加。这些增加在青春期成熟结束时最为明显，可能与骨转换减少有关。
本研究利用一种相当准确且易于获得的技术，提供了生长发育期个体骨量的规范数据。所得结果表明，男性和女性之间的大多数差异以及随年龄的变化与骨骼尺寸的变化而非密度有关。
