delta-Opioid receptor: the third extracellular loop determines naltrindole selectivity.
作者信息
Li X, Varga E V, Stropova D, Zalewska T, Malatynska E, Knapp R J, Roeske W R, Yamamura H I
机构信息
Department of Pharmacology, College of Medicine, University of Arizona, Tucson 85724, USA.
出版信息
Eur J Pharmacol. 1996 Apr 4;300(1-2):R1-2. doi: 10.1016/0014-2999(96)00098-2.
PMID:8741185
Abstract
Human delta/mu-opioid receptor chimeras were constructed to determine the role of the second and third extracellular loops in alkaloid ligand selectivity. Exchanging the third extracellular loop of the delta-opioid receptor with that of the mu-opioid receptor dramatically decreased the affinity of naltrindole, but not that of morphine. The results suggest that different domains of the opioid receptor are involved in the binding of naltrindole and morphine.
摘要
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