Vankan W J, Huyghe J M, Janssen J D, Huson A
Department of Mechanical Engineering, Eindhoven University of Technology, The Netherlands.
Eur J Morphol. 1996;34(1):19-24. doi: 10.1076/ejom.34.1.19.13159.
A finite element description of blood perfusion has been developed, and is applied to skeletal muscles. Three-dimensional distributions of blood pressures and flows in deforming muscles are calculated. The muscle tissue is considered as a fluid-saturated porous solid. The blood is modeled as a series of five intercommunicating compartmental fluids, representing arterial, arteriolar, capillary, venular and venous blood, that reside in the pores (blood vessels) of the muscle tissue. The blood vessels are modeled as distensible tubes, embedded in the muscle tissue. A 3-D finite element mesh has been mapped on a reconstructed geometry of a gastrocnemius medialis muscle of the rat. Blood perfused linear elastic muscle material behaviour has been assigned to this mesh. A simulation of blood perfusion, resulting from a constant arterio-venous pressure difference, through the reconstructed muscle has been performed. Calculated blood pressure and flow distributions were within physiological range.
已开发出血液灌注的有限元描述，并将其应用于骨骼肌。计算了变形肌肉中血压和血流的三维分布。肌肉组织被视为流体饱和的多孔固体。血液被建模为一系列五个相互连通的隔室流体，分别代表动脉血、小动脉血、毛细血管血、小静脉血和静脉血，它们存在于肌肉组织的孔隙（血管）中。血管被建模为嵌入肌肉组织中的可扩张管。一个三维有限元网格已映射到大鼠内侧腓肠肌的重建几何形状上。已为该网格指定了血液灌注的线性弹性肌肉材料行为。通过重建的肌肉进行了由恒定动静脉压差引起的血液灌注模拟。计算得到的血压和血流分布在生理范围内。
