Van Donkelaar C C, Kretzers L J, Bovendeerd P H, Lataster L M, Nicolay K, Janssen J D, Drost M R
Department of Movement Sciences, Cardiovascular Research Institute Maastricht, The Netherlands.
J Anat. 1999 Jan;194 ( Pt 1)(Pt 1):79-88. doi: 10.1046/j.1469-7580.1999.19410079.x.
In numerical simulations of skeletal muscle contractions, geometric information is of major importance. The aim of the present study was to determine whether the diffusion tensor imaging (DTI) technique is suitable to obtain valid input with regard to skeletal muscle fibre direction. The accuracy of the DTI method was therefore studied by comparison of DTI fibre directions in the rat tibialis anterior muscle with fascicle striation patterns visible on high-resolution magnetic resonance imaging (MRI) and with fibre directions in an actual longitudinal section (ALS) through the same muscle. The results showed an excellent qualitative agreement between high-resolution MRI and DTI. Despite less accurate quantitative comparison with ALS, it was concluded that DTI does indeed measure skeletal muscle fibre direction. After the experiment, it was possible to determine an appropriate voxel size (0.9 mm3) that provided enough resolution and acceptable accuracy (5 degrees) to use DTI fibre directions in biomechanical analyses. Muscle deformation during contraction, resulting from a finite element simulation with a mesh that was directly generated from the experimental data, has been presented.
在骨骼肌收缩的数值模拟中，几何信息至关重要。本研究的目的是确定扩散张量成像（DTI）技术是否适合获取有关骨骼肌纤维方向的有效输入信息。因此，通过将大鼠胫骨前肌的DTI纤维方向与高分辨率磁共振成像（MRI）上可见的肌束条纹模式以及通过同一块肌肉的实际纵切面（ALS）中的纤维方向进行比较，研究了DTI方法的准确性。结果显示高分辨率MRI与DTI之间在定性上具有极好的一致性。尽管与ALS的定量比较不太准确，但得出的结论是DTI确实能够测量骨骼肌纤维方向。实验后，有可能确定一个合适的体素大小（0.9立方毫米），该大小提供了足够的分辨率和可接受的精度（5度），以便在生物力学分析中使用DTI纤维方向。文中还展示了在收缩过程中肌肉的变形情况，这是通过使用直接从实验数据生成的网格进行有限元模拟得到的。
