Vankan W J, Huyghe J M, Slaaf D W, van Donkelaar C C, Drost M R, Janssen J D, Huson A
Department of Mechanical Engineering, Eindhoven University of Technology, The Netherlands.
Am J Physiol. 1997 Sep;273(3 Pt 2):H1587-94. doi: 10.1152/ajpheart.1997.273.3.H1587.
Mechanical interaction between tissue stress and blood perfusion in skeletal muscles plays an important role in blood flow impediment during sustained contraction. The exact mechanism of this interaction is not clear, and experimental investigation of this mechanism is difficult. We developed a finite-element model of the mechanical behavior of blood-perfused muscle tissue, which accounts for mechanical blood-tissue interaction in maximally vasodilated vasculature. Verification of the model was performed by comparing finite-element results of blood pressure and flow with experimental measurements in a muscle that is subject to well-controlled mechanical loading conditions. In addition, we performed simulations of blood perfusion during tetanic, isometric contraction and maximal vasodilation in a simplified, two-dimensional finite-element model of a rat calf muscle. A vascular waterfall in the venous compartment was identified as the main cause for blood flow impediment both in the experiment and in the finite-element simulations. The validated finite-element model offers possibilities for detailed analysis of blood perfusion in three-dimensional muscle models under complicated loading conditions.
骨骼肌组织应力与血液灌注之间的机械相互作用在持续收缩期间的血流阻碍中起着重要作用。这种相互作用的确切机制尚不清楚，并且对该机制进行实验研究也很困难。我们开发了一个血液灌注肌肉组织力学行为的有限元模型，该模型考虑了最大血管舒张状态下血管系统中的机械血液 - 组织相互作用。通过将血压和血流的有限元结果与在受到良好控制的机械加载条件下的肌肉中的实验测量值进行比较，对模型进行了验证。此外，我们在大鼠小腿肌肉的简化二维有限元模型中进行了强直等长收缩和最大血管舒张期间的血液灌注模拟。静脉腔中的血管瀑布被确定为实验和有限元模拟中血流阻碍的主要原因。经过验证的有限元模型为在复杂加载条件下对三维肌肉模型中的血液灌注进行详细分析提供了可能性。
