Platelet density and size in inflammatory bowel disease.

OBJECTIVE

The present study investigates platelet density and mean platelet volume (MPV) in active inflammatory bowel disease (IBD).

EXPERIMENTAL PROTOCOL

27 patients with IBD (18 ulcerative colitis and 9 Crohn's disease) were compared to 12 healthy volunteers. 18 subjects had active disease. Platelet counts and mean platelet volume (MPV) were determined. Thereafter, platelets were separated according to density on a linear preformed Percoll gradient. A computerized device was employed for scanning transmission variations and thus the platelet distribution in the gradient and the platelet peak were identified.

RESULTS AND CONCLUSIONS

Subjects with active IBD had greater platelet density (p = 0.02) and lower MPVs (p < 0.001). These findings may indicate augmented platelet granule content. The study also demonstrates that a low MPV is associated with active IBD.