Kes P, Ratković-Gusić I
Department of Nephrology and Dialysis, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
Kidney Int Suppl. 1996 Jun;55:S72-4.
The effect of arterial hypertension on the progression of chronic renal failure (CRF) was evaluated in 108 patients who eventually required dialysis in the 8 year period of the study. Patients' average serum creatinine (SCr) concentration at first examination was 239.7 +/- 45.3 mumol/liter and at the start of dialysis was 1,661.0 +/- 181.9 mumol/liter. The mean duration of pre-dialysis follow-up was 53.7 +/- 15.7 months. The mean monthly increase in SCr was 18.8 +/- 13.4 and 2.1 +/- 1.4 mumol/liter/month in hypertensive and normotensive CRF patients, respectively (P < 0.001). The CRF patients with a diastolic blood pressure (BP) < 89 mm Hg had a significantly (P < 0.05) slower rate of decline in renal function than the patients with a diastolic BP > or = 90 mm Hg. There was a significant relationship between a mean diastolic BP > or = 90 mm Hg and the rate of monthly increase in SCr (r = 0.81, P < 0.001). These data indicate that control of diastolic BP in CRF patients is a potentially effective way to slow the rate of decline in renal function.
在这项为期8年的研究中，对108例最终需要透析的患者评估了动脉高血压对慢性肾衰竭（CRF）进展的影响。患者首次检查时的平均血清肌酐（SCr）浓度为239.7±45.3μmol/升，开始透析时为1661.0±181.9μmol/升。透析前随访的平均持续时间为53.7±15.7个月。高血压和血压正常的CRF患者SCr的平均每月升高分别为18.8±13.4和2.1±1.4μmol/升/月（P<0.001）。舒张压（BP）<89mmHg的CRF患者肾功能下降速度明显（P<0.05）慢于舒张压BP≥90mmHg的患者。平均舒张压≥90mmHg与SCr每月升高速率之间存在显著关系（r=0.81，P<0.001）。这些数据表明，控制CRF患者的舒张压是减缓肾功能下降速率的一种潜在有效方法。
