Heller J, Kramer H J, Cervenka L, Hellerová S
Institute of Clinical Experimental Medicine, Prague, Czech Republic.
Kidney Int Suppl. 1996 Jun;55:S113-4.
Administration of losartan (L), an angiotensin II receptor antagonist, at a daily dose of 3 mg/kg body wt, lowered systolic blood pressure (SBP) in both the Prague hypertensive rat and the Prague normotensive rat (PNR). Proteinuria was markedly reduced in both strains by L. Seven days after kidney ischemia due to bilateral clamping of both renal arteries for 45 minutes, the renal function (endogenous creatinine clearance, sodium, potassium, and urea excretion rates) was completely normal in L-treated PHR and PNR, whereas distinct deterioration was observed in untreated animals. The survival rate after kidney ischemia was significantly improved by L in both PHR and PNR. Thus, L had a significant blood pressure-lowering action in both strains and exerted a distinct renal protective effect from kidney ischemia.
给予氯沙坦（L），一种血管紧张素II受体拮抗剂，每日剂量为3毫克/千克体重，可降低布拉格高血压大鼠和布拉格正常血压大鼠（PNR）的收缩压（SBP）。L可使两种品系的蛋白尿明显减少。在双侧肾动脉夹闭45分钟导致肾脏缺血7天后，接受L治疗的PHR和PNR的肾功能（内生肌酐清除率、钠、钾和尿素排泄率）完全正常，而未治疗的动物则出现明显恶化。L可显著提高PHR和PNR在肾脏缺血后的存活率。因此，L在两种品系中均具有显著的降压作用，并对肾脏缺血具有明显的肾脏保护作用。
