Spiers D E, Kelleher S A, Eichen P A
Animal Sciences Department, University of Missouri, Columbia 65211, USA.
Pharmacol Biochem Behav. 1996 Jul;54(3):555-64. doi: 10.1016/0091-3057(95)02218-x.
Rats at thermoneutral ambient temperature (Ta) exhibit change in thermoregulatory response to ethanol (EtOH) from 2 to 15 days of age. In the present study, rats at 2-3, 8-9, and 14-15 days of age were administered either saline or EtOH (4 g/kg b.wt.;IP) using two different routines to determine EtOH effect on specific cold defense mechanisms. Injection of EtOH in the first routine occurred after exposure to cold Ta, to determine effect on maintenance of cold thermogenesis. EtOH-induced metabolic depression increased from 3 to 8 days of age, with little change after this time. Injection of EtOH in the second routine was at thermoneutral Ta, followed at 20 min postinjection by rapid exposure to cold Ta to determine effect on activation of cold thermogenesis. EtOH-treatment delayed onset of cold thermogenesis at 2-3 and 14-15 days of age, and completely eliminated 8-9-day-old response to cold Ta. Rats exposed to cold Ta at 2-3 days of age exhibited a slower rate of EtOH absorption and lower blood EtOH concentration than rats in the older groups, to explain some age differences in EtOH response.
处于热中性环境温度（Ta）的大鼠在2至15日龄时对乙醇（EtOH）的体温调节反应会发生变化。在本研究中，对2 - 3日龄、8 - 9日龄和14 - 15日龄的大鼠使用两种不同的程序给予生理盐水或乙醇（4 g/kg体重；腹腔注射），以确定乙醇对特定冷防御机制的影响。在第一种程序中，在暴露于低温Ta后注射乙醇，以确定对维持冷产热的影响。乙醇诱导的代谢抑制从3日龄增加到8日龄，此后变化不大。在第二种程序中，在热中性Ta下注射乙醇，注射后20分钟迅速暴露于低温Ta，以确定对冷产热激活的影响。乙醇处理在2 - 3日龄和14 - 15日龄时延迟了冷产热的开始，并完全消除了8 - 9日龄大鼠对低温Ta的反应。与年龄较大的组相比，2 - 3日龄暴露于低温Ta的大鼠乙醇吸收速率较慢，血液乙醇浓度较低，这解释了乙醇反应中的一些年龄差异。
