Swan G E, Carmelli D, Cardon L R
Health Sciences Program, SRI International, Menlo Park, CA 94025, USA.
J Subst Abuse. 1996;8(1):19-31. doi: 10.1016/s0899-3289(96)90055-3.
Despite the fact that epidemiologic studies demonstrate a consistent covariation between the use of tobacco, alcohol, and coffee, most previous behavioral genetic-studies have determined the contribution of genetic and environmental influences as if the consumption of these substances occurred independently of each other. In this study, we used multivariate structural equation modeling to determine the genetic and environmental overlap in the observed correlations between tobacco smoking and alcohol and coffee drinking in 173 monozygotic and 183 dizygotic male twin pairs (M age = 59 years; range = 52-66 years) who participated in a follow-up cardiovascular examination of the National Heart, Lung, and Blood Institute's Twin Study. Consistent with hypothesized psychoneurogenetic predispositions for the joint use of these substances, the most parsimonious model fitting these data identified a common genetic latent factor underlying the observed associations between smoking, alcohol, and coffee use in this cohort. This factor, herein called polysubstance use, underscores the role of genetic influence on the clustering of these behaviors in the same individual.
尽管流行病学研究表明烟草、酒精和咖啡的使用之间存在一致的共变关系，但此前大多数行为遗传学研究在确定基因和环境影响的作用时，都假定这些物质的消费是相互独立发生的。在本研究中，我们使用多变量结构方程模型，来确定参与美国国立心肺血液研究所双胞胎研究后续心血管检查的173对同卵男性双胞胎和183对异卵男性双胞胎（年龄中位数 = 59岁；范围 = 52 - 66岁）中，吸烟与饮酒及喝咖啡之间观察到的相关性中的基因和环境重叠情况。与这些物质联合使用的心理神经遗传易感性假设一致，拟合这些数据的最简约模型确定了一个共同的基因潜在因素，该因素是该队列中吸烟、饮酒和咖啡使用之间观察到的关联的基础。这个因素，在此称为多物质使用，强调了基因影响在同一个体中这些行为聚类方面的作用。
