Swan G E, Carmelli D, Cardon L R
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA.
J Stud Alcohol. 1997 Mar;58(2):182-90. doi: 10.15288/jsa.1997.58.182.
To determine the relative contribution of environmental and genetic influences on the joint distribution of heavy smoking, heavy alcohol use and heavy coffee drinking.
Multivariate structural equation modeling in a large cohort of male twins (N = 2,220 monozygotic and 2,373 dizygotic twin pairs; mean age = 62.1 years) from the National Academy of Sciences-National Research Council's World War II Twin Registry.
The best-fitting model identified two independent (i.e., uncorrelated) sets of genetic and environmental latent factors, with one set underlying joint heavy smoking and heavy alcohol use and the other set underlying joint heavy smoking and heavy coffee drinking (chi 2 = 14,13,22 df, p > .80). Heavy alcohol use and heavy coffee drinking were uncorrelated in this sample. While common genetic factors accounted for 35% to 78% of the total genetic variance in heavy substance use, a substantial amount of genetic variance remained specific to each of the three substances.
Several hypotheses involving genetic and environmental factors are presented to account for the independent clustering of heavy smoking and heavy alcohol use and of heavy smoking and heavy coffee drinking.
确定环境和遗传因素对重度吸烟、重度饮酒和重度咖啡饮用联合分布的相对贡献。
对来自美国国家科学院-国家研究委员会二战双胞胎登记处的一大群男性双胞胎（2220对同卵双胞胎和2373对异卵双胞胎；平均年龄=62.1岁）进行多变量结构方程建模。
最佳拟合模型确定了两组独立（即不相关）的遗传和环境潜在因素，一组是重度吸烟和重度饮酒的潜在因素，另一组是重度吸烟和重度咖啡饮用的潜在因素（卡方=14,13,22自由度，p>.80）。在这个样本中，重度饮酒和重度咖啡饮用不相关。虽然共同遗传因素占重度物质使用总遗传方差的35%至78%，但仍有相当数量的遗传方差是这三种物质各自特有的。
提出了几个涉及遗传和环境因素的假设，以解释重度吸烟和重度饮酒以及重度吸烟和重度咖啡饮用的独立聚类现象。
