Ormsby A H, Haskell R, Ruthven S E, Mylne G E
Department of Anatomical Pathology, Gosford Hospital, NSW.
Pathology. 1996 May;28(2):196-200. doi: 10.1080/00313029600169883.
We report a rare case of bilateral primary seminal vesicle carcinoma in a 73 yr old Australian man. To our knowledge this case report is the 48th histologically confirmed case of primary seminal vesicle neoplasia and only the fourth reported case of primary bilateral seminal vesicle carcinoma. Macroscopically the tumor was localized to both seminal vesicles and the adjacent right lobe of the prostate. Histologically the tumor and metastases displayed a PSA, PAP and CEA negative, well differentiated papillary adenocarcinoma resembling the pattern of normal seminal vesicle epithelium. No other primary carcinoma in the body was demonstrated. The patient survived for 3 yrs and 4 mths without recurrence of tumor. The pathological criteria for acceptance of primary seminal vesicle carcinoma, difficulties in clinical/radiological detection of seminal vesicle tumors and CA-125 immunoreactivity are discussed.
我们报告了一例罕见的73岁澳大利亚男性双侧原发性精囊癌病例。据我们所知，该病例报告是第48例经组织学确诊的原发性精囊肿瘤病例，也是仅有的第四例双侧原发性精囊癌报告病例。大体上，肿瘤局限于双侧精囊及相邻的前列腺右叶。组织学上，肿瘤及转移灶表现为前列腺特异性抗原（PSA）、前列腺酸性磷酸酶（PAP）和癌胚抗原（CEA）阴性，高分化乳头状腺癌，类似正常精囊上皮的形态。体内未发现其他原发性癌。患者存活了3年4个月，肿瘤未复发。本文还讨论了原发性精囊癌的病理诊断标准、精囊肿瘤临床/放射学检测的困难以及CA-125免疫反应性。
