Lal Hira, Yadav Priyank, Jena Rahul, Jain Manoj
Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
BMJ Case Rep. 2017 Oct 10;2017:bcr-2017-221896. doi: 10.1136/bcr-2017-221896.
Primary seminal vesicle adenocarcinoma is one of the rarest genitourinary cancers. The pathogenesis is unknown and clinical manifestations are protean. There is no defined treatment for this disease and various combinations of surgery, chemotherapy, radiation therapy and hormonal therapy have been used in the past. Here, we have reported a primary seminal vesicle adenocarcinoma with hepatic metastases, managed with multiagent chemotherapy (oxaliplatin and 5-fluorouracil based) and androgen ablation (with triptorelin). The key to management of such a case is early diagnosis and multimodal treatment. The reported survival rate continues to be poor even for a localised disease. A consolidated follow-up protocol ensures early diagnosis of recurrent or metastatic disease so that second-line therapy can be started.
原发性精囊腺癌是最罕见的泌尿生殖系统癌症之一。其发病机制尚不清楚，临床表现多样。目前尚无针对该疾病的明确治疗方法，过去曾使用过手术、化疗、放疗和激素治疗的各种组合。在此，我们报告了一例伴有肝转移的原发性精囊腺癌，采用多药化疗（基于奥沙利铂和5-氟尿嘧啶）和雄激素剥夺（使用曲普瑞林）进行治疗。处理此类病例的关键是早期诊断和多模式治疗。即使是局限性疾病，报道的生存率仍然很低。统一的随访方案可确保早期诊断复发或转移性疾病，从而能够开始二线治疗。
