Panté N, Aebi U
Me Müller Institute for Microscopy, Biozentrum, University of Basel, Switzerland.
Curr Opin Cell Biol. 1996 Jun;8(3):397-406. doi: 10.1016/s0955-0674(96)80016-0.
Transport of proteins, RNAs and ribonucleoprotein particles into and out of the nucleus is essential for many cellular functions to proceed. Recent progress in this area of research has led to the identification of a number of signals and cytosolic factors that mediate the nuclear import of proteins through the nuclear pore complexes. However, as the sites on the nuclear pore complex at which these signals and factors exert their function are still largely unidentified, the molecular mechanisms underlying this nuclear import pathway remain to be elucidated.
蛋白质、RNA和核糖核蛋白颗粒进出细胞核的运输对于许多细胞功能的进行至关重要。该研究领域的最新进展已导致鉴定出许多信号和胞质因子，它们通过核孔复合体介导蛋白质的核输入。然而，由于这些信号和因子发挥功能的核孔复合体上的位点在很大程度上仍未明确，这种核输入途径的分子机制仍有待阐明。
