构象刚性二聚体磁共振成像剂的设计。

Design of conformationally rigid dimeric MRI agents.

作者信息

Shukla R, Fernandez M, Pillai R K, Ranganathan R, Ratsep P C, Zhang X, Tweedle M F

机构信息

Bracco Research USA, Princeton, New Jersey 08540, USA.

出版信息

Magn Reson Med. 1996 Jun;35(6):928-31. doi: 10.1002/mrm.1910350623.

DOI:10.1002/mrm.1910350623

PMID:8744023

Abstract

The conformational flexibility of the linkage mechanism or tether between paramagnetic metal centers is explored to assess optimal structural characteristics of multimeric MRI contrast agents. Two dimeric paramagnetic chelates differing in linkage flexibility but similar in symmetry are compared Relaxivity, water hydration number, and reorientational times of the chelate groups are obtained, and the results demonstrate that greater linkage flexibility reduces overall relaxivity.

摘要

研究顺磁性金属中心之间连接机制或连接链的构象灵活性，以评估多聚体磁共振成像（MRI）造影剂的最佳结构特征。比较了两种连接灵活性不同但对称性相似的二聚体顺磁性螯合物。获得了螯合物基团的弛豫率、水合水数量和重排时间，结果表明更大的连接灵活性会降低整体弛豫率。