Johnson D B, Dell'Italia L J
Birmingham Veteran Affairs Medical Center, University of Alabama at Birmingham, Department of Medicine, Alabama, USA.
Curr Opin Nephrol Hypertens. 1996 Mar;5(2):186-91. doi: 10.1097/00041552-199603000-00016.
Left ventricular hypertrophy is both a major adaptive response to chronic pressure overload and an important risk factor in patients with hypertension. It is now well appreciated that structural changes in the myocardium are mediated not only by the mechanical stress of pressure overload but also by various neurohormonal substances that exert trophic effects on myocytes and non-myocytes in the heart. Both earlier recognition and improved understanding of cardiac hypertrophy may lead to more effective therapeutic strategies for hypertension. This review focuses on the underlying mechanisms in hypertensive heart disease that lead to heart failure.
左心室肥厚既是对慢性压力超负荷的主要适应性反应，也是高血压患者的重要危险因素。现在人们已经充分认识到，心肌的结构变化不仅由压力超负荷的机械应力介导，还由各种对心脏中的心肌细胞和非心肌细胞发挥营养作用的神经激素物质介导。对心脏肥大的早期识别和更好理解都可能带来更有效的高血压治疗策略。本综述重点关注导致高血压性心脏病心力衰竭的潜在机制。
