Glastonbury J R, Morton J G, Matthews L M
NSW Agriculture, Regional Veterinary Laboratory, Wagga, Australia.
J Vet Diagn Invest. 1996 Apr;8(2):202-9. doi: 10.1177/104063879600800210.
An epizootic of disease attributed to infection with Streptobacillus moniliformis occurred in a colony of Swiss white mice. The mortality rate among the 180 breeding females in the 6 affected pens was 100%, and most of the sucking young died from starvation. Acute septicemia, subacute septicemia, and polyarthritis were the 3 forms of disease observed. Clinically, septicemic mice either were found dead or were depressed and hunched for 1-2 days prior to death. About a half of these mice had brown skin crusts overlying the mammae. Pathologic findings in cases of acute septicemia were few; in mice with subacute septicemia, there was acute, multifocal, suppurative, embolic interstitial nephritis, and the arthritic form was characterized by many subcutaneous and periarticular abscesses. Severe, acute, diffuse neutrophilic dermatitis was responsible for the brown skin crusts. The S. moniliformis isolate conformed morphologically and physiologically to classical descriptions of the organism. The infection may have gained entry to the colony via wild rats.
一群瑞士小白鼠中发生了一场由念珠状链杆菌感染引起的 epizootic。6 个受影响围栏中的 180 只繁殖母鼠死亡率为 100%，大多数哺乳幼崽死于饥饿。观察到的疾病有急性败血症、亚急性败血症和多关节炎 3 种形式。临床上，患败血症的小鼠要么被发现死亡，要么在死前 1 - 2 天表现出萎靡和弓背。这些小鼠中约有一半在乳房上有褐色皮肤结痂。急性败血症病例的病理发现较少；亚急性败血症小鼠有急性、多灶性、化脓性、栓塞性间质性肾炎，关节炎形式的特征是许多皮下和关节周围脓肿。严重的急性弥漫性嗜中性皮炎导致了褐色皮肤结痂。分离出的念珠状链杆菌在形态和生理上与该生物体的经典描述相符。感染可能是通过野鼠进入鼠群的。
