Hayashimoto Nobuhito, Yoshida Hideaki, Goto Kazuo, Takakura Akira
ICLAS Monitoring Center, Central Institute for Experimental Animals, Miyamae-ku, Kanagawa, Japan.
J Vet Med Sci. 2008 May;70(5):493-5. doi: 10.1292/jvms.70.493.
We isolated Streptobacillus moniliformis, the causative agent of rat-bite fever in humans, from the salivary gland of a pet rat postmortem. The isolate was a Gram-negative pleomorphic coccobacillus, which produced acid from glucose and showed enzymatic activities for eight items in the API ZYM system. The results were consistent with those of the reference strain, ATCC 14647(T), except for acid production from dextrin. Partial sequencing of 16S rRNA (1,440 bp) and gyrB genes (514 bp) of the isolate revealed similarities of 100% and 99.8%, respectively, to those of S. moniliformis in GenBank. Therefore, the isolate was identified as S. moniliformis. These results suggested the potential risk of rat-bite fever arising from pet rats in Japan.
我们在一只宠物鼠死后从其唾液腺中分离出念珠状链杆菌，该菌是人类鼠咬热的病原体。分离出的菌株为革兰氏阴性多形性球杆菌，可利用葡萄糖产酸，并在API ZYM系统中对八项指标表现出酶活性。除了从糊精产酸外，结果与参考菌株ATCC 14647(T)一致。对该分离株的16S rRNA（1440 bp）和gyrB基因（514 bp）进行部分测序，结果显示其与GenBank中念珠状链杆菌的相似性分别为100%和99.8%。因此，该分离株被鉴定为念珠状链杆菌。这些结果表明日本宠物鼠存在引发鼠咬热的潜在风险。
