Zorlu C G, Cobanoglu O
Division of Gynecologic Oncology, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Int J Gynaecol Obstet. 1995 Dec;51(3):235-8. doi: 10.1016/0020-7292(95)80012-3.
To evaluate the efficacy of medical treatment in patients with lichen sclerosus (LS), squamous hyperplasia (SH) and lichen sclerosus with associated squamous hyperplasia.
Forty-eight patients with non-neoplastic epithelial disorders of the vulva, SH in 23 (47.9%), LS in 20 (41.6%) and LS with associated SH in five (10.5%) were diagnosed and treated in our clinic. Patients with LS were treated with 2% testosterone ointment. Topical fluorinated corticosteroids was the treatment of choice in patients with SH. Patients with LS with associated SH were treated with topical fluorinated corticosteroid application followed by testosterone propionate ointment.
The clinical response rate of SH to first-line therapy was 95.6% with a correlation of 90.5% with histological reversal; this rate was 80% with a histological correlation of 81.3% in LS. The remission rates of SH and LS patients following a full course of therapy were 100% and 90%, respectively. In LS with associated SH patients, 90% responded to standard therapy with a remission rate of 100% after completion of a full course of therapy.
Medical therapy of lichen sclerosus and squamous hyperplasia was very effective with a good clinical and histologic correlation.
评估药物治疗在外阴硬化性苔藓（LS）、鳞状上皮增生（SH）以及合并鳞状上皮增生的硬化性苔藓患者中的疗效。
48例患有外阴非肿瘤性上皮疾病的患者在我们诊所接受诊断和治疗，其中23例（47.9%）为鳞状上皮增生，20例（41.6%）为硬化性苔藓，5例（10.5%）为合并鳞状上皮增生的硬化性苔藓。硬化性苔藓患者用2%睾酮软膏治疗。外用氟化皮质类固醇是鳞状上皮增生患者的首选治疗方法。合并鳞状上皮增生的硬化性苔藓患者先外用氟化皮质类固醇，然后用丙酸睾酮软膏治疗。
鳞状上皮增生患者一线治疗的临床有效率为95.6%，与组织学逆转的相关性为90.5%；硬化性苔藓患者的这一比例为80%，与组织学的相关性为81.3%。鳞状上皮增生和硬化性苔藓患者全疗程治疗后的缓解率分别为100%和90%。在合并鳞状上皮增生的硬化性苔藓患者中，90%对标准治疗有反应，全疗程治疗后缓解率为100%。
硬化性苔藓和鳞状上皮增生的药物治疗非常有效，临床和组织学相关性良好。
