Ayhan A, Tuncer Z S, Kaya H
Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
Eur J Gynaecol Oncol. 1997;18(2):139-40.
To determine the effectiveness of medical therapy in vulvar dystrophy, a retrospective, single-institute clinicopathologic study of 285 consecutive cases was carried out. Of the patients, 152 (53.3%) had squamous hyperplasia (SH), 72 (25.3%) had lichen sclerosus (LS), and 61 (21.4%) had lichen sclerosus with areas of squamous hyperplasia (LS + SH). Symptomatic response was 84.8% at 3 months and 92.7% at 6 months in patients with SH. These figures were 70.8% and 87.5% for patients with LS and 68.8% and 80.3% for patients with SH + LS, respectively. Histopathological response was 63.6% at 3 months and 74.8% at 6 months for patients with SH. These figures were approximately 29% and 42% for LS, and 21% and 34% for patients with SH + LS, respectively. Corticosteroids for squamous hyperplasia and testosterone for lichen sclerosus achieved a high symptomatic response. However, histologic remission rates were poorer.
为确定药物治疗在外阴营养不良中的有效性，我们对连续285例病例进行了一项回顾性、单机构临床病理研究。在这些患者中，152例（53.3%）患有鳞状上皮增生（SH），72例（25.3%）患有硬化性苔藓（LS），61例（21.4%）患有伴有鳞状上皮增生区域的硬化性苔藓（LS+SH）。SH患者在3个月时的症状缓解率为84.8%，6个月时为92.7%。LS患者的这些数字分别为70.8%和87.5%，SH+LS患者分别为68.8%和80.3%。SH患者在3个月时的组织病理学缓解率为63.6%，6个月时为74.8%。LS患者的这些数字分别约为29%和42%，SH+LS患者分别为21%和34%。用于鳞状上皮增生的皮质类固醇和用于硬化性苔藓的睾酮取得了较高的症状缓解率。然而，组织学缓解率较差。
