日本的人类白细胞抗原（HLA）抗原与重症肌无力

HLA antigens and myasthenia gravis in Japan.

作者信息

Yoshida T, Tsuchiya M, Ono A, Yoshimatsu H, Satoyoshi E, Tsuji K

出版信息

J Neurol Sci. 1977 Jun;32(2):195-201. doi: 10.1016/0022-510x(77)90234-9.

Abstract

Recent studies have noted an increased association of the histocompatibility antigen HLA-B8 with myasthenia gravis in Caucasian patients. The HLA types of 63 Japanese patients with myasthenia were compared to those of 271 controls. The present study was designed to assess correlations between HLA antigens, sex, age at onset, the presence of autoantibodies and thymic morphology. HLA-B12 was increased Japanese patients, especially females with early age at onset, and in addition it was significantly correlated with thymic hyperplasia. HLA-B5 was frequently found in the patients with thymoma. Statistically the most frequent haplotype found in this disease was HLA-A10-HLA-B12.

摘要

近期研究指出，在白种人患者中，组织相容性抗原HLA - B8与重症肌无力的关联性增强。对63例日本重症肌无力患者的HLA类型与271例对照者进行了比较。本研究旨在评估HLA抗原、性别、发病年龄、自身抗体的存在情况与胸腺形态之间的相关性。HLA - B12在日本患者中有所增加，尤其是发病年龄较早的女性，此外，它与胸腺增生显著相关。HLA - B5在胸腺瘤患者中经常出现。从统计学角度来看，该疾病中最常见的单倍型是HLA - A10 - HLA - B12。