印度北部的人类白细胞抗原与重症肌无力
HLA antigens and myasthenia gravis in north India.
作者信息
Mehra N K, Ahuja G K, Taneja V, Vaidya M C
出版信息
J Neurol Neurosurg Psychiatry. 1983 Apr;46(4):361-4. doi: 10.1136/jnnp.46.4.361.
The HLA antigen distribution was studied in 37 north Indian patients with myasthenia gravis. The control group consisted of 118 normal, healthy individuals of the same ethnic group. The antigens showing the highest frequency were Bw21 (18.9% vs 4.2% p less than 0.005), Bw35 (24.3% vs 6.8%, p less than 0.005) and A9 (51.3% vs 30.5%, p less than 0.025). HLA-B8 was increased nearly two fold in the myasthenia gravis patients (RR = 2.4) and was confined mainly to the young females without thymoma. The possibility that Bw21 and Bw35 might be the markers for susceptibility to autoimmune disorders in India is discussed. The observations also support those of others that HLA-B8 linked susceptibility gene is more frequently found in myasthenia gravis patients with thymic hyperplasia.
对37名北印度重症肌无力患者的HLA抗原分布情况进行了研究。对照组由118名同种族的正常健康个体组成。出现频率最高的抗原有Bw21（18.9% 对比4.2%，p小于0.005）、Bw35（24.3% 对比6.8%，p小于0.005）和A9（51.3% 对比30.5%，p小于0.025）。HLA - B8在重症肌无力患者中增加了近两倍（相对危险度 = 2.4），且主要局限于无胸腺瘤的年轻女性。文中讨论了Bw21和Bw35可能是印度自身免疫性疾病易感性标志物的可能性。这些观察结果也支持了其他人的观点，即与HLA - B8相关的易感基因在胸腺增生的重症肌无力患者中更常见。
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