Takuma H, Kawagishi T, Kyogoku I, Okuno Y, Nishizawa Y, Morii H
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Diabetes Res Clin Pract. 1995 Oct;30(1):69-73. doi: 10.1016/0168-8227(95)01147-1.
A generalized hypersensitivity reaction against human insulin was demonstrated in a non-insulin dependent diabetic man treated with only human insulin. The patient had no history of previous insulin exposure or atopy. Because of negative reactions to intracutaneous tests of constituents of the formulation and the presence of insulin-specific IgE antibody, this generalized allergic reaction seems to have been caused by the human insulin itself. Although desensitization was not effective, this allergic reaction was improved both by the treatment with oral antihistamines and desensitization. Cases of generalized and primary allergy against human insulin have been rarely reported making this a very rare case.
在一名仅接受人胰岛素治疗的非胰岛素依赖型糖尿病男性患者中，证实了对人胰岛素的全身性超敏反应。该患者既往无胰岛素暴露史或特应性病史。由于对制剂成分的皮内试验呈阴性反应且存在胰岛素特异性IgE抗体，这种全身性过敏反应似乎是由人胰岛素本身引起的。尽管脱敏治疗无效，但口服抗组胺药治疗和脱敏治疗均使这种过敏反应有所改善。既往很少报道对人胰岛素的全身性原发性过敏病例，因此这是一个非常罕见的病例。
