Chaouat G, Menu E, Delage G, Moreau J F, Khrishnan L, Hui L, Meliani A A, Martal J, Raghupathy R, Lelaidier C
Department of Obstetrics and Gynaecology, INSERM CJF 92-09, Hospital Béclére, Clamart, France.
Hum Reprod. 1995 Dec;10 Suppl 2:55-9. doi: 10.1093/humrep/10.suppl_2.55.
First we recall briefly the status of inflammatory cytokines in the early implantation period. We then describe the status of leukaemia inhibiting factor (LIF) production in an in-vitro, relatively short-term, human decidual explant culture system. We show that in most infertile women with recurrent implantation failure following successful in-vitro fertilization, LIF production is statistically much lower than normal. Other parameters of LIF production in vitro are summarized briefly, and the effects of RU486 are shown. The TH2 status of normal pregnancy is described, together with the production of TH2 cytokines by decidua and placenta. These cytokines are deficient in the CBAXDBA/2 model of murine spontaneous early pregnancy loss. The defect can be corrected by alloimmunization, and more importantly by the injection of tau interferon. The significance of these data for early pregnancy signalling is discussed.
首先，我们简要回顾一下着床早期炎症细胞因子的状况。然后，我们描述在体外相对短期的人蜕膜外植体培养系统中白血病抑制因子（LIF）的产生情况。我们发现，在大多数体外受精成功后反复着床失败的不孕妇女中，LIF的产生在统计学上远低于正常水平。我们还简要总结了体外LIF产生的其他参数，并展示了RU486的作用。文中描述了正常妊娠的TH2状态，以及蜕膜和胎盘产生TH2细胞因子的情况。在CBAXDBA/2小鼠自发性早期妊娠丢失模型中，这些细胞因子缺乏。这种缺陷可以通过同种免疫来纠正，更重要的是可以通过注射τ干扰素来纠正。我们还讨论了这些数据对早期妊娠信号传导的意义。
