Piccinni M P, Scaletti C, Maggi E, Romagnani S
Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 Viale Morgagni, 50134, Florence, Italy.
J Neuroimmunol. 2000 Sep 1;109(1):30-3. doi: 10.1016/s0165-5728(00)00299-x.
Development of CD4+ helper T (Th) cells into type 1 (Th1) or type 2 (Th2) effectors, as characterized by their opposite pattern of cytokine production, can be influenced by several factors, including hormones. Progesterone promotes the production of IL-4 and IL-5, whereas relaxin promotes the production of IFN-gamma by T cells. Leukemia inhibitory factor (LIF), essential for embryo implantation, is up-regulated by IL-4 and progesterone. Moreover, the production of LIF and/or Th2 cytokines by decidual T cells contributes to the maintenance of pregnancy. Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy.
CD4 +辅助性T（Th）细胞分化为1型（Th1）或2型（Th2）效应细胞，其特征在于它们产生细胞因子的模式相反，这可能受到多种因素的影响，包括激素。孕酮促进IL - 4和IL - 5的产生，而松弛素促进T细胞产生IFN - γ。白血病抑制因子（LIF）对胚胎着床至关重要，它受IL - 4和孕酮上调。此外，蜕膜T细胞产生LIF和/或Th2细胞因子有助于维持妊娠。我们的结果表明，松弛素和孕酮可能有助于调节孕期的免疫稳态。
