Saravanan N, Senthil D, Varalakshmi P
Department of Medical Biochemistry, University of Madras, India.
Pharmacol Res. 1995 Sep;32(3):165-9. doi: 10.1016/s1043-6618(05)80010-6.
Oxalate, the major stone-forming constituent induces lipid peroxidation during lithogenesis. In experimental condition oxalate formation was induced by the administration of its precursor glycollate. Glycollate-fed rats showed increased susceptibility to lipid peroxidation in the presence of promoters. In addition, antioxidant enzymes-catalase, superoxide dismutase and glutathione peroxidase also showed decreased activity. Reduced glutathione, total thiols and ascorbic acid were also significantly decreased. On the other hand, an increased xanthine oxidase and decreased glucose-6-phosphate dehydrogenase activity was also observed upon glycollate administration. Cysteine, a sulphydryl compound, is known to inhibit free radical toxicity in various pathologies. Cysteine administration to glycollate-fed rats brought about a significant decrease in the peroxidative level, with an increase in the antioxidant status.
草酸盐是主要的结石形成成分，在结石形成过程中会诱导脂质过氧化。在实验条件下，通过给予其前体乙醇酸盐来诱导草酸盐的形成。喂食乙醇酸盐的大鼠在有促进剂存在的情况下对脂质过氧化的易感性增加。此外，抗氧化酶——过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性也降低。还原型谷胱甘肽、总硫醇和抗坏血酸也显著减少。另一方面，给予乙醇酸盐后还观察到黄嘌呤氧化酶活性增加，葡萄糖-6-磷酸脱氢酶活性降低。半胱氨酸是一种巯基化合物，已知在各种病理情况下能抑制自由基毒性。给喂食乙醇酸盐的大鼠注射半胱氨酸可使过氧化水平显著降低，同时抗氧化状态增强。
